Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrP(Sc), an aggregated, misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). Stable variations in PrP(Sc) conformation...

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Detalhes bibliográficos
Main Authors: Laferrière, Florent, Tixador, Philippe, Moudjou, Mohammed, Chapuis, Jérôme, Sibille, Pierre, Herzog, Laetitia, Reine, Fabienne, Jaumain, Emilie, Laude, Hubert, Rezaei, Human, Béringue, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795044/
https://ncbi.nlm.nih.gov/pubmed/24130496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003702
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