Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

Prions are proteinaceous infectious agents responsible for fatal neurodegenerative diseases in animals and humans. They are essentially composed of PrP(Sc), an aggregated, misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). Stable variations in PrP(Sc) conformation...

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Bibliographic Details
Main Authors: Laferrière, Florent, Tixador, Philippe, Moudjou, Mohammed, Chapuis, Jérôme, Sibille, Pierre, Herzog, Laetitia, Reine, Fabienne, Jaumain, Emilie, Laude, Hubert, Rezaei, Human, Béringue, Vincent
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795044/
https://ncbi.nlm.nih.gov/pubmed/24130496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003702
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