Integrity of Helix 2-Helix 3 Domain of the PrP Protein Is Not Mandatory for Prion Replication

The process of prion conversion is not yet well understood at the molecular level. The regions critical for the conformational change of PrP remain mostly debated and the extent of sequence change acceptable for prion conversion is poorly documented. To achieve progress on these issues, we applied a...

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Detalhes bibliográficos
Main Authors: Salamat, Khalid, Moudjou, Mohammed, Chapuis, Jérôme, Herzog, Laetitia, Jaumain, Emilie, Béringue, Vincent, Rezaei, Human, Pastore, Annalisa, Laude, Hubert, Dron, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365929/
https://ncbi.nlm.nih.gov/pubmed/22511770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341677
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