Integrity of Helix 2-Helix 3 Domain of the PrP Protein Is Not Mandatory for Prion Replication

The process of prion conversion is not yet well understood at the molecular level. The regions critical for the conformational change of PrP remain mostly debated and the extent of sequence change acceptable for prion conversion is poorly documented. To achieve progress on these issues, we applied a...

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Autors principals: Salamat, Khalid, Moudjou, Mohammed, Chapuis, Jérôme, Herzog, Laetitia, Jaumain, Emilie, Béringue, Vincent, Rezaei, Human, Pastore, Annalisa, Laude, Hubert, Dron, Michel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365929/
https://ncbi.nlm.nih.gov/pubmed/22511770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341677
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