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Mammalian prions: Tolerance to sequence changes—how far?
Upon prion infection, abnormal prion protein (PrP(Sc)) self-perpetuate by conformational conversion of α-helix-rich PrP(C) into β sheet enriched form, leading to formation and deposition of PrP(Sc) aggregates in affected brains. However the process remains poorly understood at the molecular level an...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609119/ https://ncbi.nlm.nih.gov/pubmed/23232499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.23110 |
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