Endogenous Proteolytic Cleavage of Disease-associated Prion Protein to Produce C2 Fragments Is Strongly Cell- and Tissue-dependent

The abnormally folded form of the prion protein (PrP(Sc)) accumulating in nervous and lymphoid tissues of prion-infected individuals can be naturally cleaved to generate a N-terminal-truncated fragment called C2. Information about the identity of the cellular proteases involved in this process and i...

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Detalhes bibliográficos
Main Authors: Dron, Michel, Moudjou, Mohammed, Chapuis, Jérôme, Salamat, Muhammad Khalid Farooq, Bernard, Julie, Cronier, Sabrina, Langevin, Christelle, Laude, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856230/
https://ncbi.nlm.nih.gov/pubmed/20154089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083857
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