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Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death

Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system by prions, where neurons and glial cells are regarded as primary targets. Neuronal loss and gliosis, associated with the accumulation of misfolded prion protein (PrP), are hallmarks of prion d...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Cronier, Sabrina, Laude, Hubert, Peyrin, Jean-Michel
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514468/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15302929/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402725101
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