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Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death
Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system by prions, where neurons and glial cells are regarded as primary targets. Neuronal loss and gliosis, associated with the accumulation of misfolded prion protein (PrP), are hallmarks of prion d...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15302929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402725101 |
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