Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification

Prions are formed of misfolded assemblies (PrP(Sc)) of the variably N-glycosylated cellular prion protein (PrP(C)). In infected species, prions replicate by seeding the conversion and polymerization of host PrP(C). Distinct prion strains can be recognized, exhibiting defined PrP(Sc) biochemical prop...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Moudjou, Mohammed, Chapuis, Jérôme, Mekrouti, Mériem, Reine, Fabienne, Herzog, Laetitia, Sibille, Pierre, Laude, Hubert, Vilette, Didier, Andréoletti, Olivier, Rezaei, Human, Dron, Michel, Béringue, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935985/
https://ncbi.nlm.nih.gov/pubmed/27384922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29116
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