The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

Prions are unconventional infectious agents thought to be primarily composed of PrP(Sc), a multimeric misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). They cause fatal neurodegenerative diseases in both animals and humans. The disease phenotype is not uniform wi...

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Autors principals: Tixador, Philippe, Herzog, Laëtitia, Reine, Fabienne, Jaumain, Emilie, Chapuis, Jérôme, Le Dur, Annick, Laude, Hubert, Béringue, Vincent
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855332/
https://ncbi.nlm.nih.gov/pubmed/20419156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000859
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