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The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent
Prions are unconventional infectious agents thought to be primarily composed of PrP(Sc), a multimeric misfolded conformer of the ubiquitously expressed host-encoded prion protein (PrP(C)). They cause fatal neurodegenerative diseases in both animals and humans. The disease phenotype is not uniform wi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2855332/ https://ncbi.nlm.nih.gov/pubmed/20419156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000859 |
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