Host prion protein expression levels impact prion tropism for the spleen

Prions are pathogens formed from abnormal conformers (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). PrP(Sc) conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Béringue, Vincent, Tixador, Philippe, Andréoletti, Olivier, Reine, Fabienne, Castille, Johan, Laï, Thanh-Lan, Le Dur, Annick, Laisné, Aude, Herzog, Laetitia, Passet, Bruno, Rezaei, Human, Vilotte, Jean-Luc, Laude, Hubert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402522/
https://ncbi.nlm.nih.gov/pubmed/32702070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008283
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