Accelerated, Spleen-Based Titration of Variant Creutzfeldt-Jakob Disease Infectivity in Transgenic Mice Expressing Human Prion Protein with Sensitivity Comparable to That of Survival Time Bioassay

The dietary exposure of the human population to the prions responsible for the bovine spongiform encephalopathy (BSE) epizooty has led to the emergence of variant Creutzfeldt-Jakob disease (vCJD). This fatal, untreatable neurodegenerative disorder is a growing public health concern because the preva...

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Detalhes bibliográficos
Main Authors: Halliez, Sophie, Reine, Fabienne, Herzog, Laetitia, Jaumain, Emilie, Haïk, Stéphane, Rezaei, Human, Vilotte, Jean-Luc, Laude, Hubert, Béringue, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135959/
https://ncbi.nlm.nih.gov/pubmed/24850746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01118-14
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