Accelerated, Spleen-Based Titration of Variant Creutzfeldt-Jakob Disease Infectivity in Transgenic Mice Expressing Human Prion Protein with Sensitivity Comparable to That of Survival Time Bioassay

The dietary exposure of the human population to the prions responsible for the bovine spongiform encephalopathy (BSE) epizooty has led to the emergence of variant Creutzfeldt-Jakob disease (vCJD). This fatal, untreatable neurodegenerative disorder is a growing public health concern because the preva...

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Hlavní autoři: Halliez, Sophie, Reine, Fabienne, Herzog, Laetitia, Jaumain, Emilie, Haïk, Stéphane, Rezaei, Human, Vilotte, Jean-Luc, Laude, Hubert, Béringue, Vincent
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Prions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135959/
https://ncbi.nlm.nih.gov/pubmed/24850746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01118-14
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