Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met(129) with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmiss...

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Main Authors: Béringue, Vincent, Herzog, Laëtitia, Reine, Fabienne, Le Dur, Annick, Casalone, Cristina, Vilotte, Jean-Luc, Laude, Hubert
Format: Artigo
Language:Inglês
Published: Centers for Disease Control and Prevention 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634647/
https://ncbi.nlm.nih.gov/pubmed/19046515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3201/eid1412.080941
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