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Divergent prion strain evolution driven by PrP(C) expression level in transgenic mice
Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrP(C) into PrP(Sc). Structurally distinct PrP(Sc) conformers can give rise to multiple prion strains. Constrained interactions between PrP(C) and different...
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| I publikationen: | Nat Commun |
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| Huvudupphovsmän: | , , , , , , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2017
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5264111/ https://ncbi.nlm.nih.gov/pubmed/28112164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14170 |
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