Divergent prion strain evolution driven by PrP(C) expression level in transgenic mice

Prions induce a fatal neurodegenerative disease in infected host brain based on the refolding and aggregation of the host-encoded prion protein PrP(C) into PrP(Sc). Structurally distinct PrP(Sc) conformers can give rise to multiple prion strains. Constrained interactions between PrP(C) and different...

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Publié dans:Nat Commun
Auteurs principaux: Le Dur, Annick, Laï, Thanh Lan, Stinnakre, Marie-George, Laisné, Aude, Chenais, Nathalie, Rakotobe, Sabine, Passet, Bruno, Reine, Fabienne, Soulier, Solange, Herzog, Laetitia, Tilly, Gaëlle, Rézaei, Human, Béringue, Vincent, Vilotte, Jean-Luc, Laude, Hubert
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264111/
https://ncbi.nlm.nih.gov/pubmed/28112164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14170
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