Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?

Prions are proteinaceous infectious agents responsible for a range of neurodegenerative diseases in animals and humans. Prion particles are assemblies formed from a misfolded, β-sheet rich, aggregation-prone isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). Prions replicate by r...

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Enregistré dans:
Détails bibliographiques
Publié dans:Viruses
Auteurs principaux: Igel-Egalon, Angélique, Bohl, Jan, Moudjou, Mohammed, Herzog, Laetitia, Reine, Fabienne, Rezaei, Human, Béringue, Vincent
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563208/
https://ncbi.nlm.nih.gov/pubmed/31083283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11050429
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