Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

Mammalian prions, the pathogens that cause transmissible spongiform encephalopathies, propagate by self-perpetuating the structural information stored in the abnormally folded, aggregated conformer (PrP(Sc)) of the host-encoded prion protein (PrP(C)). To date, no structural model related to prion as...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Igel-Egalon, Angélique, Moudjou, Mohammed, Martin, Davy, Busley, Alexandra, Knäpple, Tina, Herzog, Laetitia, Reine, Fabienne, Lepejova, Nad’a, Richard, Charles-Adrien, Béringue, Vincent, Rezaei, Human
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589264/
https://ncbi.nlm.nih.gov/pubmed/28880932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006557
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