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Pharmacological Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage
The clinical potential of pharmacological ascorbate (P-AscH(−); IV delivery achieving mM concentrations in blood) as an adjuvant in cancer therapy is being re-evaluated. At mM concentrations, P-AscH(−) is thought to exhibit anti-cancer activity via generation of a flux of H(2)O(2) in tumors, which l...
Tallennettuna:
| Julkaisussa: | Mol Cancer Res |
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| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6774825/ https://ncbi.nlm.nih.gov/pubmed/31337671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0381 |
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