Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer

Pharmacologic ascorbate (P-AscH(–)) is emerging as a promising adjuvant for advanced pancreatic cancer. P-AscH(–)generates hydrogen peroxide (H(2)O(2)), leading to selective cancer cell cytotoxicity. Catalytic manganoporphyrins, such as MnT4MPyP, can increase the rate of oxidation of P-AscH(–), ther...

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Udgivet i:Radiat Res
Main Authors: Alexander, Matthew S., O’Leary, Brianne R., Wilkes, Justin G., Gibson, Adrienne R., Wagner, Brett A., Du, Juan, Sarsour, Ehab, Hwang, Rosa F., Buettner, Garry R., Cullen, Joseph J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441967/
https://ncbi.nlm.nih.gov/pubmed/30376411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15189.1
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