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Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer
Pharmacologic ascorbate (P-AscH(–)) is emerging as a promising adjuvant for advanced pancreatic cancer. P-AscH(–)generates hydrogen peroxide (H(2)O(2)), leading to selective cancer cell cytotoxicity. Catalytic manganoporphyrins, such as MnT4MPyP, can increase the rate of oxidation of P-AscH(–), ther...
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Publicado no: | Radiat Res |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6441967/ https://ncbi.nlm.nih.gov/pubmed/30376411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15189.1 |
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