Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer

Chemoradiation therapy is the mainstay for treatment of locally advanced, borderline resectable pancreatic cancer. Pharmacological ascorbate (P-AscH(-), i.e., intravenous infusions of ascorbic acid, vitamin C), but not oral ascorbate, produces high plasma concentrations capable of selective cytotoxi...

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Publicado no:Cancer Res
Main Authors: Alexander, Matthew S., Wilkes, Justin. G., Schroeder, Samuel R., Buettner, Garry R., Wagner, Brett A., Du, Juan, Gibson-Corley, Katherine, O’Leary, Brianne R., Spitz, Douglas R., Buatti, John M., Berg, Daniel J., Bodeker, Kellie L., Vollstedt, Sandy, Brown, Heather A., Allen, Bryan G., Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295907/
https://ncbi.nlm.nih.gov/pubmed/30254147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1680
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