Pharmacologic ascorbate (P-AscH(−)) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma

HIF-1α is a transcriptional regulator that functions in the adaptation of cells to hypoxic conditions; it strongly impacts the prognosis of patients with cancer. High-dose, intravenous, pharmacological ascorbate (P-AscH(−)), induces cytotoxicity and oxidative stress selectively in cancer cells by ac...

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Detalhes bibliográficos
Publicado no:Clin Exp Metastasis
Main Authors: Wilkes, Justin G., O’Leary, Brianne R., Du, Juan, Klinger, Adrienne R., Sibenaller, Zita A., Doskey, Claire M., Gibson-Corley, Katherine N., Alexander, Matthew S., Tsai, Susan, Buettner, Garry R., Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959274/
https://ncbi.nlm.nih.gov/pubmed/29396728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-018-9876-z
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