Extracellular Superoxide Dismutase (EcSOD) Suppresses Hypoxia-Inducible Factor-1α (HIF-1α) in Pancreatic Cancer

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low oxygen environment. Clinically, HIF-1α appears to...

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Bibliographic Details
Main Authors: Sibenaller, Zita A., Welsh, Jessemae L., Du, Changbin, Witmer, Jordan R., Schrock, Hannah E., Du, Juan, Buettner, Garry R., Goswami, Prabhat C., Cieslak, John A., Cullen, Joseph J.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981470/
https://ncbi.nlm.nih.gov/pubmed/24509158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.02.002
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