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Extracellular Superoxide Dismutase (EcSOD) Suppresses Hypoxia-Inducible Factor-1α (HIF-1α) in Pancreatic Cancer
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that governs cellular responses to reduced oxygen availability by mediating crucial homeostatic processes and is a major survival determinant for tumor cells growing in a low oxygen environment. Clinically, HIF-1α appears to...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981470/ https://ncbi.nlm.nih.gov/pubmed/24509158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.02.002 |
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