Loss of SOD3 (EcSOD) expression promotes an aggressive phenotype in human pancreatic ductal adenocarcinoma

PURPOSE: Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme th...

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Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: O’Leary, Brianne R., Fath, Melissa A., Bellizzi, Andrew M., Hrabe, Jennifer E., Button, Anna M., Allen, Bryan G., Case, Adam J., Altekruse, Sean, Wagner, Brett A., Buettner, Garry R., Lynch, Charles F., Hernandez, Brenda Y., Cozen, Wendy, Beardsley, Robert A., Keene, Jeffery, Henry, Michael D., Domann, Frederick E., Spitz, Douglas R., Mezhir, James J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383686/
https://ncbi.nlm.nih.gov/pubmed/25634994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1959
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