Loss of SOD3 (EcSOD) expression promotes an aggressive phenotype in human pancreatic ductal adenocarcinoma

PURPOSE: Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme th...

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Publicado no:Clin Cancer Res
Main Authors: O’Leary, Brianne R., Fath, Melissa A., Bellizzi, Andrew M., Hrabe, Jennifer E., Button, Anna M., Allen, Bryan G., Case, Adam J., Altekruse, Sean, Wagner, Brett A., Buettner, Garry R., Lynch, Charles F., Hernandez, Brenda Y., Cozen, Wendy, Beardsley, Robert A., Keene, Jeffery, Henry, Michael D., Domann, Frederick E., Spitz, Douglas R., Mezhir, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383686/
https://ncbi.nlm.nih.gov/pubmed/25634994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1959
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