Loss of SOD3 (EcSOD) expression promotes an aggressive phenotype in human pancreatic ductal adenocarcinoma

PURPOSE: Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme th...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: O’Leary, Brianne R., Fath, Melissa A., Bellizzi, Andrew M., Hrabe, Jennifer E., Button, Anna M., Allen, Bryan G., Case, Adam J., Altekruse, Sean, Wagner, Brett A., Buettner, Garry R., Lynch, Charles F., Hernandez, Brenda Y., Cozen, Wendy, Beardsley, Robert A., Keene, Jeffery, Henry, Michael D., Domann, Frederick E., Spitz, Douglas R., Mezhir, James J.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383686/
https://ncbi.nlm.nih.gov/pubmed/25634994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1959
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