Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

The toxicity of pharmacological ascorbate is mediated by the generation of H(2)O(2) via the oxidation of ascorbate. Since pancreatic cancer cells are sensitive to H(2)O(2) generated by ascorbate they would also be expected to become sensitized to agents that increase oxidative damage such as ionizin...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Du, Juan, Cieslak, John A., Welsh, Jessemae L., Sibenaller, Zita A., Allen, Bryan G., Wagner, Brett A., Kalen, Amanda L., Doskey, Claire M., Strother, Robert K., Button, Anna M., Mott, Sarah L., Smith, Brian, Tsai, Susan, Mezhir, James, Goswami, Prabhat C., Spitz, Douglas R., Buettner, Garry R., Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537815/
https://ncbi.nlm.nih.gov/pubmed/26081808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1707
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