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Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H(2)O(2) generation
Renewed interest in using pharmacological ascorbate (AscH(−)) to treat cancer has prompted interest in leveraging its cytotoxic mechanism of action. A central feature of AscH(−) action in cancer cells is its ability to act as an electron donor to O(2) for generating H(2)O(2). We hypothesized that ca...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3745518/ https://ncbi.nlm.nih.gov/pubmed/23764544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0470 |
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