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MECHANISMS OF ASCORBATE-INDUCED CYTOTOXICITY IN PANCREATIC CANCER

PURPOSE: Pharmacological concentrations of ascorbate may be effective in cancer therapeutics. We hypothesized that ascorbate concentrations achievable with intravenous dosing would be cytotoxic in pancreatic cancer where the five-year survival is < 3%. EXPERIMENTAL DESIGN: Pancreatic cancer cell...

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Detalhes bibliográficos
Main Authors: Du, Juan, Martin, Sean M., Levine, Mark, Wagner, Brett A., Buettner, Garry R., Wang, Sih-han, Taghiyev, Agshin F., Du, Changbin, Knudson, C. Michael, Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807999/
https://ncbi.nlm.nih.gov/pubmed/20068072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1713
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