BIMG-07. PHARMACOLOGICAL ASCORBATE ENHANCES RADIATION AND TEMOZOLOMIDE EFFECTIVENESS IN GLIOBLASTOMA BY A MECHANISM MEDIATED BY REDOX ACTIVE IRON

Pharmacological ascorbate (P-AscH(-); high dose intravenous infusions of vitamin C generating milli-molar plasma concentrations) has re-emerged as an anti-cancer therapy. Phase 1 clinical trials combining P-AscH(-) with chemotherapy and ionizing radiation demonstrate safety and promising clinical ou...

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Bibliographische Detailangaben
Veröffentlicht in:Neurooncol Adv
Hauptverfasser: Allen, Bryan, Petronek, Michael, Monga, Varun, Bodeker, Kellie, Smith, Brian, Buettner, Garry, Greenlee, Jeremy, Smith, Mark, Spitz, Douglas, Cullen, Joseph, Magnotta, Vincent, Buatti, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
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Supplement Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992261/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.006
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