Redox active metals and H(2)O(2) mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models()

Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20 mM pl...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Schoenfeld, Joshua D., Sibenaller, Zita A., Mapuskar, Kranti A., Bradley, Megan D., Wagner, Brett A., Buettner, Garry R., Monga, Varun, Milhem, Mohammed, Spitz, Douglas R., Allen, Bryan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651553/
https://ncbi.nlm.nih.gov/pubmed/29069637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.012
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