Redox active metals and H(2)O(2) mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models()

Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20 mM pl...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Schoenfeld, Joshua D., Sibenaller, Zita A., Mapuskar, Kranti A., Bradley, Megan D., Wagner, Brett A., Buettner, Garry R., Monga, Varun, Milhem, Mohammed, Spitz, Douglas R., Allen, Bryan G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651553/
https://ncbi.nlm.nih.gov/pubmed/29069637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.012
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