Redox active metals and H(2)O(2) mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models()

Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20 mM pl...

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發表在:Redox Biol
Main Authors: Schoenfeld, Joshua D., Sibenaller, Zita A., Mapuskar, Kranti A., Bradley, Megan D., Wagner, Brett A., Buettner, Garry R., Monga, Varun, Milhem, Mohammed, Spitz, Douglas R., Allen, Bryan G.
格式: Artigo
語言:Inglês
出版: Elsevier 2017
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651553/
https://ncbi.nlm.nih.gov/pubmed/29069637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.09.012
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