Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Pharmacological ascorbate (P-AscH(-)) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that paramagnetic iron (Fe(3+)) catalyzes ascorbate's...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Cushing, Cameron M., Petronek, Michael S., Bodeker, Kellie L., Vollstedt, Sandy, Brown, Heather A., Opat, Emyleigh, Hollenbeck, Nancy J., Shanks, Thomas, Berg, Daniel J., Smith, Brian J., Smith, Mark C., Monga, Varun, Furqan, Muhammad, Howard, Matthew A., Greenlee, Jeremy D., Mapuskar, Kranti A., St-Aubin, Joel, Flynn, Ryan T., Cullen, Joseph J., Buettner, Garry R., Spitz, Douglas R., Buatti, John M., Allen, Bryan G., Magnotta, Vincent A.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708874/
https://ncbi.nlm.nih.gov/pubmed/33260088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101804
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