Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Pharmacological ascorbate (P-AscH(-)) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that paramagnetic iron (Fe(3+)) catalyzes ascorbate's...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Cushing, Cameron M., Petronek, Michael S., Bodeker, Kellie L., Vollstedt, Sandy, Brown, Heather A., Opat, Emyleigh, Hollenbeck, Nancy J., Shanks, Thomas, Berg, Daniel J., Smith, Brian J., Smith, Mark C., Monga, Varun, Furqan, Muhammad, Howard, Matthew A., Greenlee, Jeremy D., Mapuskar, Kranti A., St-Aubin, Joel, Flynn, Ryan T., Cullen, Joseph J., Buettner, Garry R., Spitz, Douglas R., Buatti, John M., Allen, Bryan G., Magnotta, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708874/
https://ncbi.nlm.nih.gov/pubmed/33260088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101804
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