Tumor cells have decreased ability to metabolize H(2)O(2): Implications for pharmacological ascorbate in cancer therapy

Ascorbate (AscH(−)) functions as a versatile reducing agent. At pharmacological doses (P-AscH(−); [plasma AscH(−)] ≥≈20 mM), achievable through intravenous delivery, oxidation of P-AscH(−) can produce a high flux of H(2)O(2) in tumors. Catalase is the major enzyme for detoxifying high concentrations...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Doskey, Claire M., Buranasudja, Visarut, Wagner, Brett A., Wilkes, Justin G., Du, Juan, Cullen, Joseph J., Buettner, Garry R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106370/
https://ncbi.nlm.nih.gov/pubmed/27833040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.010
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