Pharmacological Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage

The clinical potential of pharmacological ascorbate (P-AscH(−); IV delivery achieving mM concentrations in blood) as an adjuvant in cancer therapy is being re-evaluated. At mM concentrations, P-AscH(−) is thought to exhibit anti-cancer activity via generation of a flux of H(2)O(2) in tumors, which l...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Cancer Res
Main Authors: Buranasudja, Visarut, Doskey, Claire M., Gibson, Adrienne R., Wagner, Brett A., Du, Juan, Gordon, David J., Koppenhafer, Stacia L., Cullen, Joseph J., Buettner, Garry R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6774825/
https://ncbi.nlm.nih.gov/pubmed/31337671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0381
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker