β-Lactones: A Novel Class of Ca(2+)-Independent Phospholipase A(2) (Group VIA iPLA(2)) Inhibitors with Ability to Inhibit β-Cell Apoptosis

Interest in Ca(2+)-independent phospholipase A(2) (GVIA iPLA(2)) has accelerated recently as it is being recognized as a participant in biological processes underlying diabetes development and autoimmune-based neurological disorders. The development of potent GVIA iPLA(2) inhibitors is of great impo...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Dedaki, Christina, Kokotou, Maroula G., Mouchlis, Varnavas D., Limnios, Dimitris, Lei, Xiaoyong, Mu, Carol T., Ramanadham, Sasanka, Magrioti, Victoria, Dennis, Edward A., Kokotos, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767909/
https://ncbi.nlm.nih.gov/pubmed/30798607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01216
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