Asparaginase immune complexes induce Fc-γRIII–dependent hypersensitivity in naive mice

Asparaginase (ASNase) is an important drug for the treatment of leukemias. However, hypersensitivity to ASNase can increase the risk of leukemia relapse. Two mechanisms of ASNase hypersensitivity have been identified in mice. The existence of a pathway involving anti-ASNase IgG and Fc-γ receptor III...

Full description

Saved in:
Bibliographic Details
Published in:FASEB J
Main Authors: Rathod, Sanjay, Ramsey, Manda, DiGiorgio, Danielle, Berrios, Roberto, Finkelman, Fred D., Fernandez, Christian A.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766650/
https://ncbi.nlm.nih.gov/pubmed/31284767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900857
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items