Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis

BACKGROUND: Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to the pathogenesis of several autoimmune and inflammatory disorders. Monoclonal antibodies that block FcγRs might suppress these diseases, but they can induce anaphylaxis. OBJECTIVE: We wanted to determine whether...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: Khodoun, Marat V., Kucuk, Zeynep Yesim, Strait, Richard T., Krishnamurthy, Durga, Janek, Kevin, Clay, Corey D., Morris, Suzanne C., Finkelman, Fred D.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215526/
https://ncbi.nlm.nih.gov/pubmed/24139828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.09.008
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