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Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII

Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase drug levels and increase the risk of relapse. The aim of this study is to identify the immunoglobulin isotypes and receptors responsible for asparagi...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Rathod, Sanjay, Ramsey, Manda, Relling, Mary V., Finkelman, Fred D., Fernandez, Christian A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355496/
https://ncbi.nlm.nih.gov/pubmed/30237274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.199448
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