Asparaginase immune complexes induce Fc-γRIII–dependent hypersensitivity in naive mice

Asparaginase (ASNase) is an important drug for the treatment of leukemias. However, hypersensitivity to ASNase can increase the risk of leukemia relapse. Two mechanisms of ASNase hypersensitivity have been identified in mice. The existence of a pathway involving anti-ASNase IgG and Fc-γ receptor III...

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Vydáno v:FASEB J
Hlavní autoři: Rathod, Sanjay, Ramsey, Manda, DiGiorgio, Danielle, Berrios, Roberto, Finkelman, Fred D., Fernandez, Christian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766650/
https://ncbi.nlm.nih.gov/pubmed/31284767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900857
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