Asparaginase immune complexes induce Fc-γRIII–dependent hypersensitivity in naive mice

Asparaginase (ASNase) is an important drug for the treatment of leukemias. However, hypersensitivity to ASNase can increase the risk of leukemia relapse. Two mechanisms of ASNase hypersensitivity have been identified in mice. The existence of a pathway involving anti-ASNase IgG and Fc-γ receptor III...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Rathod, Sanjay, Ramsey, Manda, DiGiorgio, Danielle, Berrios, Roberto, Finkelman, Fred D., Fernandez, Christian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766650/
https://ncbi.nlm.nih.gov/pubmed/31284767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900857
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