Asparaginase immune complexes induce Fc-γRIII–dependent hypersensitivity in naive mice

Asparaginase (ASNase) is an important drug for the treatment of leukemias. However, hypersensitivity to ASNase can increase the risk of leukemia relapse. Two mechanisms of ASNase hypersensitivity have been identified in mice. The existence of a pathway involving anti-ASNase IgG and Fc-γ receptor III...

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Udgivet i:FASEB J
Main Authors: Rathod, Sanjay, Ramsey, Manda, DiGiorgio, Danielle, Berrios, Roberto, Finkelman, Fred D., Fernandez, Christian A.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766650/
https://ncbi.nlm.nih.gov/pubmed/31284767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900857
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