Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice

The family of nuclear factor of activated T cells (NFAT) transcription factors plays a critical role in mediating immune responses. Our previous clinical pharmacogenetic studies suggested that NFATC2 is associated with the risk of hypersensitivity reactions to the chemotherapeutic agent L-asparagina...

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Udgivet i:Blood Adv
Main Authors: Rathod, Sanjay, Ramsey, Manda, Finkelman, Fred D., Fernandez, Christian A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509855/
https://ncbi.nlm.nih.gov/pubmed/32931581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002478
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