Genome-wide analysis links NFATC2 with asparaginase hypersensitivity

Asparaginase is used to treat acute lymphoblastic leukemia (ALL); however, hypersensitivity reactions can lead to suboptimal asparaginase exposure. Our objective was to use a genome-wide approach to identify loci associated with asparaginase hypersensitivity in children with ALL enrolled on St. Jude...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Fernandez, Christian A., Smith, Colton, Yang, Wenjian, Mullighan, Charles G., Qu, Chunxu, Larsen, Eric, Bowman, W. Paul, Liu, Chengcheng, Ramsey, Laura B., Chang, Tamara, Karol, Seth E., Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Hunger, Stephen P., Carroll, William L., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Devidas, Meenakshi, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492197/
https://ncbi.nlm.nih.gov/pubmed/25987655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-628800
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