HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies

Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukocyte...

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Detalhes bibliográficos
Main Authors: Fernandez, Christian A., Smith, Colton, Yang, Wenjian, Daté, Mihir, Bashford, Donald, Larsen, Eric, Bowman, W. Paul, Liu, Chengcheng, Ramsey, Laura B., Chang, Tamara, Turner, Victoria, Loh, Mignon L., Raetz, Elizabeth A., Winick, Naomi J., Hunger, Stephen P., Carroll, William L., Onengut-Gumuscu, Suna, Chen, Wei-Min, Concannon, Patrick, Rich, Stephen S., Scheet, Paul, Jeha, Sima, Pui, Ching-Hon, Evans, William E., Devidas, Meenakshi, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141516/
https://ncbi.nlm.nih.gov/pubmed/24970932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-563742
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