Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4

The efficacy of asparaginase in acute lymphoblastic leukemia (ALL) is dependent on depletion of asparagine, an essential amino acid for ALL cells. The target level of plasma asparaginase activity to achieve asparagine depletion has been between 0.05–0.4 IU/mL. COG AALL07P4 examined the asparaginase...

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Bibliografiset tiedot
Julkaisussa:Leuk Lymphoma
Päätekijät: Schore, Reuven J, Devidas, Meenakshi, Bleyer, Archie, Reaman, Gregory H, Winick, Naomi, Loh, Mignon L, Raetz, Elizabeth A, Carroll, William L, Hunger, Stephen P, Angiolillo, Anne L
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594900/
https://ncbi.nlm.nih.gov/pubmed/30626253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2018.1542146
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