Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4

The efficacy of asparaginase in acute lymphoblastic leukemia (ALL) is dependent on depletion of asparagine, an essential amino acid for ALL cells. The target level of plasma asparaginase activity to achieve asparagine depletion has been between 0.05–0.4 IU/mL. COG AALL07P4 examined the asparaginase...

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Bibliographic Details
Published in:Leuk Lymphoma
Main Authors: Schore, Reuven J, Devidas, Meenakshi, Bleyer, Archie, Reaman, Gregory H, Winick, Naomi, Loh, Mignon L, Raetz, Elizabeth A, Carroll, William L, Hunger, Stephen P, Angiolillo, Anne L
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594900/
https://ncbi.nlm.nih.gov/pubmed/30626253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2018.1542146
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