Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4

The efficacy of asparaginase in acute lymphoblastic leukemia (ALL) is dependent on depletion of asparagine, an essential amino acid for ALL cells. The target level of plasma asparaginase activity to achieve asparagine depletion has been between 0.05–0.4 IU/mL. COG AALL07P4 examined the asparaginase...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leuk Lymphoma
Prif Awduron: Schore, Reuven J, Devidas, Meenakshi, Bleyer, Archie, Reaman, Gregory H, Winick, Naomi, Loh, Mignon L, Raetz, Elizabeth A, Carroll, William L, Hunger, Stephen P, Angiolillo, Anne L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594900/
https://ncbi.nlm.nih.gov/pubmed/30626253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2018.1542146
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