Higher Plasma Asparaginase Activity after Intramuscular than Intravenous Erwinia Asparaginase

It is unclear if dosing intervals for Erwinase can be extended with intramuscular (IM) vs intravenous (IV) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30,000–42,000 IU/m(2) IV or IM. IM Erwinase (n=22) achieved activity above 0.1 IU/mL for longer than IV Erwinase (n=33) (...

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Bibliografiske detaljer
Udgivet i:	Pediatr Blood Cancer
Main Authors:	Panetta, John C, Liu, Yiwei, Swanson, Hope D, Karol, Seth E, Pui, Ching-Hon, Inaba, Hiroto, Jeha, Sima, Relling, Mary V
Format:	Artigo
Sprog:	Inglês
Udgivet:	2020
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7253324/ https://ncbi.nlm.nih.gov/pubmed/32323890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28244
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Higher Plasma Asparaginase Activity after Intramuscular than Intravenous Erwinia Asparaginase

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