Higher Plasma Asparaginase Activity after Intramuscular than Intravenous Erwinia Asparaginase

It is unclear if dosing intervals for Erwinase can be extended with intramuscular (IM) vs intravenous (IV) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30,000–42,000 IU/m(2) IV or IM. IM Erwinase (n=22) achieved activity above 0.1 IU/mL for longer than IV Erwinase (n=33) (...

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發表在:Pediatr Blood Cancer
Main Authors: Panetta, John C, Liu, Yiwei, Swanson, Hope D, Karol, Seth E, Pui, Ching-Hon, Inaba, Hiroto, Jeha, Sima, Relling, Mary V
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253324/
https://ncbi.nlm.nih.gov/pubmed/32323890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28244
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