Higher Plasma Asparaginase Activity after Intramuscular than Intravenous Erwinia Asparaginase

It is unclear if dosing intervals for Erwinase can be extended with intramuscular (IM) vs intravenous (IV) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30,000–42,000 IU/m(2) IV or IM. IM Erwinase (n=22) achieved activity above 0.1 IU/mL for longer than IV Erwinase (n=33) (...

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Foilsithe in:Pediatr Blood Cancer
Main Authors: Panetta, John C, Liu, Yiwei, Swanson, Hope D, Karol, Seth E, Pui, Ching-Hon, Inaba, Hiroto, Jeha, Sima, Relling, Mary V
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253324/
https://ncbi.nlm.nih.gov/pubmed/32323890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28244
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