Genome-wide study of methotrexate clearance replicates SLCO1B1

Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with ALL treated with methotrexate (24-hour infusion of a 1 g/m(2) dose or 4-hour infusion of a 2 g/m(2) dose) on the Childr...

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Detalhes bibliográficos
Main Authors: Ramsey, Laura B., Panetta, John C., Smith, Colton, Yang, Wenjian, Fan, Yiping, Winick, Naomi J., Martin, Paul L., Cheng, Cheng, Devidas, Meenakshi, Pui, Ching-Hon, Evans, William E., Hunger, Stephen P., Loh, Mignon, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567337/
https://ncbi.nlm.nih.gov/pubmed/23233662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-452839
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