Genome-wide study of methotrexate clearance replicates SLCO1B1

Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic leukemia (ALL). We estimated methotrexate plasma clearance for 1279 patients with ALL treated with methotrexate (24-hour infusion of a 1 g/m(2) dose or 4-hour infusion of a 2 g/m(2) dose) on the Childr...

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Hauptverfasser: Ramsey, Laura B., Panetta, John C., Smith, Colton, Yang, Wenjian, Fan, Yiping, Winick, Naomi J., Martin, Paul L., Cheng, Cheng, Devidas, Meenakshi, Pui, Ching-Hon, Evans, William E., Hunger, Stephen P., Loh, Mignon, Relling, Mary V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Clinical Trials and Observations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567337/
https://ncbi.nlm.nih.gov/pubmed/23233662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-452839
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