Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia

Methotrexate polyglutamates (MTXPGs) determine in vivo efficacy in acute lymphoblastic leukemia (ALL). MTXPG accumulation differs by leukemic subtypes, but genomic determinants of MTXPG variation in ALL remain unclear. We analyzed 3 types of whole genome variation: leukemia cell gene expression and...

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Autori principali: French, Deborah, Yang, Wenjian, Cheng, Cheng, Raimondi, Susana C., Mullighan, Charles G., Downing, James R., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Clinical Trials and Observations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680361/
https://ncbi.nlm.nih.gov/pubmed/19066393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-172106
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