Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia

Methotrexate polyglutamates (MTXPGs) determine in vivo efficacy in acute lymphoblastic leukemia (ALL). MTXPG accumulation differs by leukemic subtypes, but genomic determinants of MTXPG variation in ALL remain unclear. We analyzed 3 types of whole genome variation: leukemia cell gene expression and...

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Bibliografiset tiedot
Päätekijät: French, Deborah, Yang, Wenjian, Cheng, Cheng, Raimondi, Susana C., Mullighan, Charles G., Downing, James R., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2009
Aiheet:
Clinical Trials and Observations
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680361/
https://ncbi.nlm.nih.gov/pubmed/19066393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-172106
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