Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia

Methotrexate polyglutamates (MTXPGs) determine in vivo efficacy in acute lymphoblastic leukemia (ALL). MTXPG accumulation differs by leukemic subtypes, but genomic determinants of MTXPG variation in ALL remain unclear. We analyzed 3 types of whole genome variation: leukemia cell gene expression and...

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Detalhes bibliográficos
Main Authors: French, Deborah, Yang, Wenjian, Cheng, Cheng, Raimondi, Susana C., Mullighan, Charles G., Downing, James R., Evans, William E., Pui, Ching-Hon, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680361/
https://ncbi.nlm.nih.gov/pubmed/19066393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-172106
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