Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo

BACKGROUND: Interpatient differences in the accumulation of methotrexate’s active polyglutamylated metabolites (MTXPGs) in leukemia cells influence its antileukemic effects. METHODS: To identify genomic and epigenomic and patient variables determining the intracellular accumulation of MTXPGs, we mea...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lopez-Lopez, Elixabet, Autry, Robert J., Smith, Colton, Yang, Wenjian, Paugh, Steven W., Panetta, John C., Crews, Kristine R., Bonten, Erik J., Smart, Brandon, Pei, Deqing, McCorkle, J. Robert, Diouf, Barthelemy, Roberts, Kathryn G., Shi, Lei, Pounds, Stanley, Cheng, Cheng, Mullighan, Charles G., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685728/
https://ncbi.nlm.nih.gov/pubmed/33164984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140797
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