Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia

Identification of genomic and epigenomic determinants of drug resistance provides important insights for improving cancer treatment. Using agnostic genome-wide interrogation of mRNA and miRNA expression, DNA methylation, SNPs, CNAs and SNVs/Indels in primary human acute lymphoblastic leukemia cells,...

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Gepubliceerd in:Nat Cancer
Hoofdauteurs: Autry, Robert J., Paugh, Steven W., Carter, Robert, Shi, Lei, Liu, Jingjing, Ferguson, Daniel C., Lau, Calvin E., Bonten, Erik J., Yang, Wenjian, McCorkle, J. Robert, Beard, Jordan A., Panetta, John C., Diedrich, Jonathan D., Crews, Kristine R., Pei, Deqing, Coke, Christopher J., Natarajan, Sivaraman, Khatamian, Alireza, Karol, Seth E., Lopez-Lopez, Elixabet, Diouf, Barthelemy, Smith, Colton, Gocho, Yoshihiro, Hagiwara, Kohei, Roberts, Kathryn G., Pounds, Stanley, Kornblau, Steven M., Stock, Wendy, Paietta, Elisabeth M., Litzow, Mark R., Inaba, Hiroto, Mullighan, Charles G., Jeha, Sima, Pui, Ching-Hon, Cheng, Cheng, Savic, Daniel, Yu, Jiyang, Gawad, Charles, Relling, Mary V., Yang, Jun J., Evans, William E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467080/
https://ncbi.nlm.nih.gov/pubmed/32885175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-0037-3
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